About Ibandronic acid Bisphosphonate derivative, Bone resorption inhibitor. Mechanism of Action of Ibandronic acid Inhibition of the enzyme farnesyl pyrophosphate synthase. Subsequently, the prenylation of GTP-binding proteins, Ibandronic acid is a potent bone resorption inhibitor, which acts on osteoclasts or on osteoclast precursors. It increases bone mineral density by reducing the rate of bone resorption. Indications for Ibandronic acid Osteoporosis Hypercalcaemia of malignancy Interactions for Ibandronic acid Impaired absorption with aluminium, calcium, iron, magnesium compounds. Increased risk of GI or renal adverse effects with NSAIDs. Additive hypocalcaemic effects with aminoglycosides.